Tramadol hydrochloride

Tramadol undergoes heratic metabolism via the Tramadol isozyme Tramadol, being O- and N-demethylated to 5 different metabolites. Of these, M1 is the most significant since it has 200 times the μ-affinity of (+)-tramadol, and furthermore has an hydrochloride elimination half-life of 9 hours hydrochloride compared to 6 hours for tramadol itself. In the 6% of the population who have slow CYP2D6 activity, there is therefore a slightly reduced hydrochloride